Ill since almost two years. Finally some blood-test-results.

2021.10.23 05:21 J1337ul Ill since almost two years. Finally some blood-test-results.

This post is about my girlfriend. she is ill for 22 months now.
Our own hypthesis is that her mitochondria can't work properly (lactate-pyruvate-ratio) because of an undersupply with oxygen (transferrin saturation). But what could be the reason for the low transferrin-saturation? It seems like and her doctor said, that she has enough iron and enough vitamins.

Please have a look at the pictures. These are the most detailed results we have.

Sex: female
weight: 57kg (125.7 lbs)
height: 176cm (5'7")


Symptoms:
- permanent vertigo in alternating intensity (worse in stressful situations)
-> started in novembedecember 2020
- extreme stress when driving train or being in a situation with other people
- low energy/exhaustion especially after eating carbonhydrates
- Overall the same feeling that people with cfs describe
- feeling like having a hangover after waking up
- dry mucus (stronger during the period, especially the eyes)
- sweating and strong body odour (especially in the armpits even after showering)
- stomach ache
- bloating
- exhaustion and stomach ache get worse 2 days before period
- caffeine makes the symptoms worse
- pressure on the sides of the neck all the time (only sometimes hurting)
- severe body aches (gets worse at night; prevents falling asleep for hours sometimes; worse in stressful situations)
- multiple inflammations in different body parts (hip, gut, foot, ...)
- intolerances against glutene, lactose, histamine (got better since 1 or 2 weeks), casein, fructose
-> started about three years ago/first symptom
- no toleration for anesthesia and many medicines (maybe because of the histamine?)
- laryngitis gastrica (severe heartache at night which often prevents falling asleep)
- hair loss
- low bloodpressure (around 90/55, lowest was 81/48)
- inner restlessness/trembling feeling like having low blood sugar and shaky legs (especially at night)
-> she already had this when she was between 9 and 11 years old and it just came back about 5 months ago; it always feels like she will loose conciousness soon; it's the worst of all symptoms; this symptom comes every few weeks and stays for several day
- sometimes a feeling like being paralyzed
- symptoms get worse after not eating enough
- symptoms get worse at hot or cold temperatures
- sometimes tachycardia when feeling very exhausted
- respiratory problems when feeling very exhausted
- no hunger
- no thirst
- difficulties in concentrating
- symptoms got worse in the time where the grass pollen flight was high (maybe cross-allergy with the food she ate in this time?)
- sometimes problem with the eyes/to focus the eyes (like being drunk)
- leaky gut
- almost every medicine has negative effects on her

Tests
- 20.07.2020 - Blood-test: erethrocytes, hemoglobin, haematocrit, sodium slightly too low; folic acid at 10.8ug/L (normal: 2-9.8 ug/L); vitamin B12 and C too high.
- 12.10.2020 - stool test: E. coli too low, Klebsiella spec. too high, Clostridium spec. too high, Bifidobacterium spec. too low, Lactobacillus spec. too low, Enterococcus spec. too low; pH at 6.5 (almost too high)
-> conclusion: putrefactive flora and histamine forming bacteria too high, protective flora too low; medium dybiosis
- 08.12.2020 - H2-breath-gas-test showed a dysbiosis in the colon too
- 21.01.2021 - blood-test: too little leukocytes, erythrocytes, hemoglobin, haematocrit; MCH (mean corpuscular hemoglobin) slightly too high; Diamineoxidase and histamine slightly too low, many (11) amino acids too low
- 29.01.2021 - stool test: leaky gut confirmed; fat and starch in stool; too little bile acid in stool
- 21.04.2021 - colonoscopy: inconspicious
- 12.05.2021 - cortisol-saliva test: no wake-up reaction of the cortisol (concentration stays at the lower bound for the whole day)
- 01.06.2021 - blood-test: too high lactate-concentration (1940 µol/L, normal: <1528); too high lactate-pyruvate-quotient (16.2, normal: <12.9); 9% damaged mitochondria (normal);
- 17.06.2020 - blood-test: too many antinuclear antibodys
- 18.06.2021 - urine-nitro-stress-test: tyrosine too low (4 mg/g creatinine; normal: 5-20 mg/g creatinine)
- 08.07.2021 - stool test: compare with 12.10.2020; Lactobacillus and Enterococcus spec. too low, all other bacteria normal; pH at 7 (too high)
-> conclusion: putrefactive flora and histamine forming bacteria normal, protective flora too low; light dybiosis
- 08.10.2021: blood test (see the pictures) + homocysteine too high 18 µmol/l (normal <10)
-> I translated everything that seems to be important
Bloodtest1
Bloodtest2
Bloodtest3
Bloodtest4

Additional Information
- Cetirizin (antihistamine) helps against the allergy-symptoms (not everytime)
- Taking Prednisolon (Cortisol) made most symptoms much worse, especially inner restlessness, severe body aches and circulatory problems
- she has mild scoliosis
- she has a titanium plate in her foot
- comparing the two stool-tests you can see it got way better, she seems to be tolerating more histamine and more food in general now
- after a special therapy the dysbiosis seems to be gone
- she is almost vegan since June 2020 (only exception high-quality-chicken every 1-2 weeks)


Thanks to everyone who read through this. We are thankful for every idea that comes to your mind. Don't hesitate to ask if something is unclear.
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